LYCACONITINE REVISITED - PARTIAL SYNTHESIS AND NEURONAL NICOTINIC ACETYLCHOLINE-RECEPTOR AFFINITIES

Authors
JACYNO JM HARWOOD JS LIN NH CAMPBELL JE SULLIVAN JP HOLLADAY MW
Citation
Jm. Jacyno et al., LYCACONITINE REVISITED - PARTIAL SYNTHESIS AND NEURONAL NICOTINIC ACETYLCHOLINE-RECEPTOR AFFINITIES, Journal of natural products, 59(7), 1996, pp. 707-709
Citations number
19
Categorie Soggetti
Chemistry,"Plant Sciences","Pharmacology & Pharmacy
Journal title
Journal of natural products → ACNP
ISSN journal
01633864
Volume
59
Issue
7
Year of publication
1996
Pages
707 - 709
Database
ISI
SICI code
0163-3864(1996)59:7<707:LR-PSA>2.0.ZU;2-7
Abstract
The norditerpenoid alkaloid lycaconitine (2) was synthesized from lyco ctonine (3) and its affinity determined for two neuronal nicotinic ace tylcholine receptor subtypes. The structure of 2 was confirmed by a co mbination of spectroscopic methods.