CHROMATOGRAPHIC-SEPARATION OF DIASTEREOMERIC SCHIFF-BASE COPPER(II), NICKEL(II), AND ZINC(II) CHELATES FROM ALPHA-AMINO-ACID RACEMATES

Chromatographic separation of diastereomeric Schiff base copper(II), n ickel(II), and zinc(II) chelates derived from optically active 3-subst ituted salicylaldehyde derivative and alpha-amino acids on a reverse-p hase column was found to be successful. The separation of two elution peaks within a pair of enantiomers was excellent for most neutral amin o acids. Optically pure alpha-amino acids were isolated from the chela tes by the addition of EDTA . 2Na. The formation of bis(Schiff base)me tal chelates with nickel(II) or zinc(II) was discussed. (C) 1996 Acade mic Press, Inc.