ANTIBODIES TO GM1 AND GAL(BETA-1-3)GALNAC AT THE NODES OF RANVIER IN HUMAN AND EXPERIMENTAL AUTOIMMUNE NEUROPATHY

Authors
THOMAS FP
Citation
Fp. Thomas, ANTIBODIES TO GM1 AND GAL(BETA-1-3)GALNAC AT THE NODES OF RANVIER IN HUMAN AND EXPERIMENTAL AUTOIMMUNE NEUROPATHY, Microscopy research and technique, 34(6), 1996, pp. 536-543
Citations number
126
Categorie Soggetti
Microscopy,Biology
Journal title
Microscopy research and technique → ACNP
ISSN journal
1059910X
Volume
34
Issue
6
Year of publication
1996
Pages
536 - 543
Database
ISI
SICI code
1059-910X(1996)34:6<536:ATGAGA>2.0.ZU;2-L
Abstract
Autoantibodies to Gal(beta 1-S)GalNAc epitopes on glycolipids and glyc oproteins are associated with motor neuron disease and motor or sensor imotor neuropathy. These epitopes are ubiquitously distributed on cell surfaces. In the nervous system they are present on axons and myelin, specifically also at the nodes of Ranvier. Binding of GM1 antibodies to the nodal area may contribute to disease development in some of the se conditions. (C) 1996 Wiley-Liss, Inc.