FUMARIA-DENSIFLORA DC ALKALOIDS

Twenty isoquinoline alkaloids were identified in the aerial part of Fu maria densiflora oc. In addition to bicuculline, densiflorine, fumarit ine, fumariline, scoulerine, coptisine, cryptopine, parfumine, protopi ne, and sinactine which have been found previously, the following alka loids were isolated for the first time from this species: adlumine, fu maricine, fumaritridine, fumarophycine, fumarofine, corytuberine, cis- N-methylstylopinium iodide, stylopine, and two new 1-benzylisoquinolin e alkaloids, viz, fumaflorine and fumaflorine methyl ester. The cytopr otectivity of extracts of F. densiflora and F. officinalis, and that o f protopine, cryptopine, and parfumine was tested on primary cultures of rat hepatocytes intoxicated with carbon tetrachloride. The cytoprot ective effect of the extracts is associated with the alkaloids.