POTENTIAL ANTAGONISTS OF EXCITATORY AMINO-ACIDS AND ANTICONVULSANTS -SOME HETEROCYCLIC (+ -)-PYRROLIDINE-2-CARBOXAMIDES/

The benzylpyrrolidine amides 1a-1d, 3a-3e, 5a, and 5b were prepared fr om N-benzyl-L-proline methyl ester with corresponding diamines. Compou nds 2a-2d, 4b, and 4e have similarly been synthesized from L-proline m ethyl ester and the corresponding diamines in refluxing methanol. In b oth cases, the reactions were accompanied by racemization. Prepared am ides were transformed to salts, suitable for pharmacological testing ( hydrogen maleates, hydrogen oxalates and hydrochlorides). The products were tested by selected methods of biochemical and behavioural pharma cology.