SYNTHESIS OF NEW L-PROLINE AMIDES WITH ANTICONVULSIVE EFFECT

Series of heterocyclic L-proline amides were prepared from BOC-L-proli ne and heterocyclic amines (mostly substituted piperazines and morphol ines) via active ester with hydroxysuccinimide. 4-(4-Fluorobenzoyl)pip eridine afforded L-proline (4-fluorobenzoyl)piperidin-1-yl)benzoyl)pip eridine (7b) simultaneously with expected L-proline 4-(4-fluorobenzoyl )piperidide (7a). D-Proline -(3-(4-(3-chlorophenyl)piperazin-1-yl)prop yl)amide (2) was prepared starting from D-proline. The amides were tes ted by methods of biochemical and behavioural pharmacology.