SYNTHESIS AND ANTITUBERCULOTIC PROPERTIES OF SOME SUBSTITUTED PYRAZINECARBOTHIOAMIDES

A series of N-substituted 3-amino-5-thiocarbamoyl-2-pyrazinecarboxamid es was prepared. The structure of compounds was confirmed by elemental analysis, IR and H-1 NMR spectra. The results of in vitro antifugal a nd antimycobacterial susceptibility testing shown no activity against pathogenic fungi and some effect on mycobacteria. The highest antitube rculotic activity (MIG within 25-50 mg ml(-1)) against Mycobacterium t uberculosis and other mycobacterial strains in this series was shown b y henylamino)-5-thiocarbamoyl-2-pyrazinecarboxamide. The antituberculo tic activity of these compounds is mostly influenced by the presence o f the thioamide moiety.