CHANGES IN SUSCEPTIBILITIES TO TEICOPLANIN, VANCOMYCIN AND OTHER ANTIBIOTICS AMONG STAPHYLOCOCCUS-AUREUS ISOLATES IN A TERTIARY-CARE UNIVERSITY HOSPITAL

Changes in antibiotics susceptibilities were evaluated among 374 nosoc omial clinical isolates of Staphylococcus aureus collected from 1986 t o 1994 in a tertiary-care University hospital where methicillin-resist ant S. aureus (MRSA) is an increasing cause of infection. Significant increases in resistance to ciprofloxacin, clindamycin and rifampicin w ere observed among MRSA isolates in recent years. No resistance to gly copeptides was observed. However, during the last 2 years a significan t trend towards a decreasing susceptibility to teicoplanin was observe d among MRSA isolates.