V. Dimarco et al., LONG-TERM INTERFERON-ALPHA TREATMENT OF CHILDREN WITH CHRONIC HEPATITIS-DELTA - A MULTICENTER STUDY, Journal of viral hepatitis, 3(3), 1996, pp. 123-128
We assessed the efficacy of prolonged interferon-alpha (IFN) therapy i
n children with chronic hepatitis caused by hepatitis delta virus (HDV
) by treating 26 paediatric cases with IFN-alpha 2b (5 MU m(-2), then
3 MU m(-2) three times weekly for 12 (medium-term group, MTG) or 24 mo
nths (long-term group, LTG). Compliance and tolerability were acceptab
le, At the end of therapy a complete biochemical response [normalizati
on of alanine aminotransferase (ALT)] occurred in 12 children (5/13 in
MTG and 7/13 in LTG), A relapse occurred after stopping IFN in 10 cas
es (five in MTG and five in LTG). Two patients from the LTG had normal
liver function tests during 12 months of follow-up. Six of the eight
hepatitis Be antigen (HBeAg) positive children lost HBeAg, while all s
ix hepatitis B virus (HBV) DNA positive patients lost HBV DNA during t
reatment, HBeAg reappeared later in two children, HDV RNA, present in
10/10 cases of MTG before treatment, persisted after 12 months IFN the
rapy in 3/10, One year after stopping therapy, 8/10 patients were agai
n HDV RNA positive, Two children cleared hepatitis delta antigen (HDVA
g) from the liver, No significant improvements in liver histology were
seen in both groups, Our experience suggests that IFN-alpha treatment
in children with chronic type D hepatitis has a transient effect, and
long-term treatment does not appear to induce a greater therapeutic b
enefit in terms of biochemical and virological response.