A NEW HEMOCOMPATIBLE PHOSPHOLIPID POLYURETHANE BASED ON HYDROGENATED POLY(ISOPRENE) SOFT SEGMENT

A new haemocompatible phospholipid polyurethane based on hydrogenated poly(isoprene) glycol (HPIP) and 4,4'-methylenediphenyl diisocyanate ( MDI) was synthesized using 2-hydroxyethyl)methylammonio]ethylstearylph osphate (BESP) and 1,4-butanediol (ED) as chain extender. The bulk and surface characteristics of this material was investigated by differen tial scanning calorimetry (DSC), dynamic viscoelasticity and tensile p roperty measurements, attenuated total reflectance-Fourier transform i nfrared spectroscopy (ATR-FTIR), and contact angle measurement. This p olymer possessed a hydrophobic surface revealed by contact angle measu rement. The haemocompatibility of this polyurethane was evaluated by p latelet rich plasma (PRP) contacting studies and scanning electron mic roscopy (SEM) observation using medical grade poly(vinyl chloride) (PV C) as the reference. The results show that this new polyurethane had r elatively lower platelet adhesion and limited shape change for the att ached platelets compared to PVC. The clotting time of the materials in contact with platelet poor plasma (PPP) was 99, 75, and 62 s and in c ontact with PRP was more than 240, 100, and 86 s for new polyurethane, PVC, and glass, respectively. This new phospholipid polyurethane is e xpected to have wide applications as coating or structural material fo r blood-contacting medical equipment due to its outstanding haemocompa tibility and excellent mechanical strength.