In REM sleep behavior disorder (RED) it has been reported that tachyca
rdia may not accompany the impressive movements associated with dream
mentation. Up to now there are no data concerning the cardiac autonomi
c activity during wakefulness, as well as during sleep out of nocturna
l dream-enacting behaviors, in RED. We evaluated 14 RED patients. Our
study shows that only 36% of patients had normal results in all tradit
ional autonomic tests during wakefulness. Moreover, RED patients had a
reduced tonic and phasic heart rate variability during sleep. Autonom
ic evaluation during sleep may show impairment earlier than the tradit
ional tests during wakefulness. No difference was found between idiopa
thic RED patients and symptomatic ones.