A SHORT TOTAL SYNTHESIS OF PALONOSETRON USING CATALYTIC-HYDROGENATION

Authors
KOWALCZYK BA
Citation
Ba. Kowalczyk, A SHORT TOTAL SYNTHESIS OF PALONOSETRON USING CATALYTIC-HYDROGENATION, Heterocycles, 43(7), 1996, pp. 1439-1446
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Heterocycles → ACNP
ISSN journal
03855414
Volume
43
Issue
7
Year of publication
1996
Pages
1439 - 1446
Database
ISI
SICI code
0385-5414(1996)43:7<1439:ASTSOP>2.0.ZU;2-Z
Abstract
The 5-HT3 receptor antagonists (1) and (2) (palonosetron) were synthes ized by an efficient new route. The critical hydrogenation of imide (4 ) was carried out with either Pd/C catalyst or PtO2 catalyst.