TRANSIENT CD80 EXPRESSION DEFECT IN A PATIENT WITH VARIABLE IMMUNODEFICIENCY AND CYCLIC NEUTROPENIA

CD80 expression on stimulated B cells of 9 common variable immunodefic iency (CVID) patients and 10 healthy control individuals was examined. Here we report on an exceptional CVID patient with recurrent episodes of cyclic neutropenia, skin vasculitis and recurrent infections assoc iated with a transient, but reproducible CD80 expression defect on sti mulated B cells. Concomitantly serum Ig levels were markedly reduced a nd B cell counts were low interestingly after recovery from an episode of neutropenia and vasculitis we observed an improvement of the CD80 expression as well as an increase in the number of B cells and a recov ery of IgM and IgG production in vivo and in vitro.