RELATIVE AND TOTAL VOLUME OF HISTOLOGICAL COMPONENTS IN BENIGN PROSTATIC HYPERPLASIA - RELATIONSHIPS BETWEEN HISTOLOGICAL COMPONENTS AND CLINICAL FINDINGS

To investigate the correlation between histological differences and cl inical findings in patients with benign prostatic hyperplasia (BPH), q uantitative morphometrical analysis on prostate was performed on 26 sp ecimens obtained by TURP. The relative and total volume of each histol ogical component were obtained. In this series, the proportion of fibr ous tissue element showed a weak positive correlation with prostatic v olume (r = 0.499, P = 0.0087). The relative volume of the smooth muscl e component showed an inverse correlation with prostatic volume (r = - 0.488, P = 0.0105). Patient age and symptom score showed no relationsh ip with the relative volume of histological components. The total volu me of all histological components increased with prostatic volume. How ever, an increase in the fibrous tissue element appeared to be predomi nant in prostatic enlargement (r = 0.970, P < 0.0001). Although the to tal volume of all histological components increased with prostatic siz e, fibrous tissue appeared to play a major role in prostatic enlargeme nt in BPH. (C) 1996 Wiley-Liss, Inc.