AUTONOMIC NEUROPATHY PREDICTS THE DEVELOPMENT OF STROKE IN PATIENTS WITH NON-INSULIN-DEPENDENT DIABETES-MELLITUS

Background and Purpose Our aim was to determine the predictive factors for stroke in patients with non-insulin-dependent diabetes mellitus ( NIDDM). Methods We studied 133 patients with NIDDM at the time of diag nosis and 5 and 10 years later. Results The number of new fatal or non fatal strokes was 19 (14.7%; 14 after 5-year examination). High initia l fasting blood glucose (odds ratio [OR], 1.2; 95% confidence interval [CI], 1.04 to 1.4) and the use of beta-blocking agents (OR, 6.7; 95% CI, 2.1 to 21.5) at baseline and the presence of parasympathetic neuro pathy (OR, 6.7; 95% CI, 1.5 to 29.9), or sympathetic autonomic nervous dysfunction (OR, 1.1; 95% CI, 1.01 to 1.2), hypertriglyceridemia (OR, 5.7; 95% CI, 1.1 to 31.0), or use of beta-blocking agents (OR, 6.4; 9 5% CI, 1.3 to 31.2), and high fasting plasma glucose (OR, 1.2; 95% CI, 1.0 to 1.5) determined at 5-year examination predicted the developmen t of stroke. Conclusions Autonomic neuropathy is an independent risk f actor for stroke in NIDDM.