SYNTHESIS AND BIOACTIVITY OF 1,3,5-SUBSTI TUTED PYRAZOL-4-METHYLENE CYCLOPROPANE CARBOXYLATE

The title compounds were synthesised by the esterification reaction of 1,3,5-substituted-4-methylol pyrazole with substituted cyclopropane c arbonyl chloride, their structure; were confirmed by means of H-1 NMR and elementary analysis. The bioassay showed that the lethal of 1, 2 a gainst mosquito larvae at 1.5x10(-7) mol/L were 100%. The killing acti vities of 1 and 2 were higher than those of pyrethroid insecticides ph enothrin (2x10(-6) mol/L) and phthalthrin (4x10(-6) mol/L). The other compounds 3,5,12 showed a higher antiphytoviral activity against TMV(t obacco mosaic virus) compared with DHT (2.4-dioxohexahydro-1,3, 5-tria zine).