INTEGRATED ON-CAPILLARY ELECTROCHEMICAL DETECTOR FOR CAPILLARY ELECTROPHORESIS

An on-capillary electrochemical detector for capillary electrophoresis is described. It consists of a gold wire mounted permanently at the e nd of the capillary perpendicular to the direction of flow. This mode of detection eliminates the need fur the micromanipulators or speciall y machined cell holders for alignment that are used for in-capillary d etection modes. It also makes it possible to perform relatively fast C EEC separations using very short capillaries. The use of this detector for both off-column detection of catecholamines and end-column detect ion of carbohydrates by CE-PAD is described.