SAR OF 2-BENZYL-4-AMINOPIPERIDINES - CGP-49823, AN ORALLY AND CENTRALLY ACTIVE NONPEPTIDE NK1 ANTAGONIST

Authors
OFNER S HAUSER K SCHILLING W VASSOUT A VEENSTRA SJ
Citation
S. Ofner et al., SAR OF 2-BENZYL-4-AMINOPIPERIDINES - CGP-49823, AN ORALLY AND CENTRALLY ACTIVE NONPEPTIDE NK1 ANTAGONIST, Bioorganic & medicinal chemistry letters, 6(14), 1996, pp. 1623-1628
Citations number
22
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
14
Year of publication
1996
Pages
1623 - 1628
Database
ISI
SICI code
0960-894X(1996)6:14<1623:SO2-CA>2.0.ZU;2-A
Abstract
Novel 2-benzyl-4-aminopiperidines have been shown to be potent and sel ective antagonists at the NK1 receptor. Some compounds of this series, e.g. CGP 49823 (2), show CNS activity after oral administration. Copy right (C) 1996 Elsevier Science Ltd