DESIGN AND SYNTHESIS OF PHOSPHINIC ACIDS THAT TRIPLY INHIBIT ENDOTHELIN-CONVERTING ENZYME, ANGIOTENSIN-CONVERTING ENZYME AND NEUTRAL ENDOPEPTIDASE-24.11
Ba. Mckittrick et al., DESIGN AND SYNTHESIS OF PHOSPHINIC ACIDS THAT TRIPLY INHIBIT ENDOTHELIN-CONVERTING ENZYME, ANGIOTENSIN-CONVERTING ENZYME AND NEUTRAL ENDOPEPTIDASE-24.11, Bioorganic & medicinal chemistry letters, 6(14), 1996, pp. 1629-1634
We have synthesized a series of phosphinic acids as inhibitors of a me
talloprotease endothelin converting enzyme (ECE). Potent ECE inhibitor
s 4g and 4o were identified. These compounds are members of a novel cl
ass of ECE inhibitors that are also potent inhibitors of angiotensin c
onverting enzyme and neutral endopeptidase. Copyright (C) 1996 Elsevie
r Science Ltd