NEW HETEROARYL-SPACED PHOSPHONO ALPHA-AMINO-ACIDS ARE COMPETITIVE NMDA ANTAGONISTS WITH ANALGESIC ACTIVITY

Authors
SWAHN BM CLAESSON A PELCMAN B BESIDSKI Y MOLIN H SANDBERG MP BERGE OG
Citation
Bm. Swahn et al., NEW HETEROARYL-SPACED PHOSPHONO ALPHA-AMINO-ACIDS ARE COMPETITIVE NMDA ANTAGONISTS WITH ANALGESIC ACTIVITY, Bioorganic & medicinal chemistry letters, 6(14), 1996, pp. 1635-1640
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
14
Year of publication
1996
Pages
1635 - 1640
Database
ISI
SICI code
0960-894X(1996)6:14<1635:NHPAAC>2.0.ZU;2-8
Abstract
The synthesis and the NMDA receptor binding affinities of -amino-3-(ph osphonomethyl)-2-naphthalene-propanoic acid, ha-amino-3-(phosphonometh yl)-2-benzofuranpropanoic acid, a series of substituted pha-amino-3-(p hosphonomethyl)-2-quinolinepropanoic acids, -3-(phosphonomethyl)-1,8-n aphthyridine-2-propanoic acid and -3-(phosphonomethyl)-1,6-naphthyridi ne-2-propanoic acid are reported. Copyright (C) 1996 Elsevier Science Ltd