ANTI-HUMAN IMMUNODEFICIENCY AND ANTI-HEPATITIS-B VIRUS ACTIVITIES OF BETA-L-2',3'-DIDEOXY PURINE NUCLEOSIDES

Authors
BOLON PJ WANG PY CHU CK GOSSELIN G BOUDOU V PIERRA C MATHE C IMBACH JL FARAJ A ALAOUI MA SOMMADOSSI JP PAI SB ZHU YL LIN JS CHENG YC SCHINAZI RF
Citation
Pj. Bolon et al., ANTI-HUMAN IMMUNODEFICIENCY AND ANTI-HEPATITIS-B VIRUS ACTIVITIES OF BETA-L-2',3'-DIDEOXY PURINE NUCLEOSIDES, Bioorganic & medicinal chemistry letters, 6(14), 1996, pp. 1657-1662
Citations number
25
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
14
Year of publication
1996
Pages
1657 - 1662
Database
ISI
SICI code
0960-894X(1996)6:14<1657:AIAAVA>2.0.ZU;2-A
Abstract
beta-L-2',3'-Dideoxyadenosine, beta-L-2',3'-didehydro-2',3'-dideoxyade nosine and related compounds were synthesized in a stereoselective man ner. These compounds were tested in vitro against HBV in 2.2.15 cell l ine and against HIV-1 in PBM and CEM cells. It was found that beta-L-2 ',3'-didehydro-2',3'-dideoxyadenosine (7) exhibited significant anti-H IV (EC(50) 0.38 mu M in PBM cells) and anti-HBV activity (EC(50) 1.2 m u M). Copyright (C) 1996 Elsevier Science Ltd