DESIGN, SYNTHESIS AND BINDING AFFINITIES OF NOVEL NONPEPTIDE MIMICS OF SOMATOSTATIN SANDOSTATIN(R)/

Authors
DAMOUR D BARREAU M BLANCHARD JC BURGEVIN MC DOBLE A HERMAN F PANTEL G JAMESSURCOUF E VUILHORGNE M MIGNANI S POITOUT L LEMERRER Y DEPEZAY JC
Citation
D. Damour et al., DESIGN, SYNTHESIS AND BINDING AFFINITIES OF NOVEL NONPEPTIDE MIMICS OF SOMATOSTATIN SANDOSTATIN(R)/, Bioorganic & medicinal chemistry letters, 6(14), 1996, pp. 1667-1672
Citations number
27
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
14
Year of publication
1996
Pages
1667 - 1672
Database
ISI
SICI code
0960-894X(1996)6:14<1667:DSABAO>2.0.ZU;2-O
Abstract
Based on molecular modelling studies of Sandostatin(R), sugar-based de rivatives I-VI were prepared as potential non-peptide mimics of somato statin/Sandostatin(R). These compounds displaced 3-[I-125]-Tyr(11)-SRI F-14 from the somatostatin receptor on membranes of rat cerebral corte x with IC50 values between 10 and 15 mu M. Copyright (C) 1996 Elsevier Science Ltd