SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF 4-AMINO TRINEMS

Authors
TRANQUILLINI ME ARALDI GL DONATI D PENTASSUGLIA G PEZZOLI A URSINI A
Citation
Me. Tranquillini et al., SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF 4-AMINO TRINEMS, Bioorganic & medicinal chemistry letters, 6(14), 1996, pp. 1683-1688
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
14
Year of publication
1996
Pages
1683 - 1688
Database
ISI
SICI code
0960-894X(1996)6:14<1683:SAAAO4>2.0.ZU;2-#
Abstract
This article deals with the study carried out on the synthesis of 4-am ino substituted trinems 1 starting from the key-intermediate -3-[(R)-1 -(t-butyldimethylsilyloxy)ethyl]-4-[(1'R, 2'S, 3'R)-1',2'-epoxycyclohe x-3'-yl]azetidin-2-one 2. In particular, epoxide opening with various amines and subsequent cyclization to the corresponding trinems were ex plored. Their synthesis and antimicrobial activity are reported. Copyr ight (C) 1996 Elsevier Science Ltd