GPI MEMBRANE ANCHORS - SYNTHESIS AND FUNCTIONAL-EVALUATION OF AMINOGLUCOSYL PHOSPHATIDYLINOSITOL CORE ANALOGS

Authors
YE JH DOERRLER WT LEHRMAN MA FALCK JR
Citation
Jh. Ye et al., GPI MEMBRANE ANCHORS - SYNTHESIS AND FUNCTIONAL-EVALUATION OF AMINOGLUCOSYL PHOSPHATIDYLINOSITOL CORE ANALOGS, Bioorganic & medicinal chemistry letters, 6(14), 1996, pp. 1715-1718
Citations number
25
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
14
Year of publication
1996
Pages
1715 - 1718
Database
ISI
SICI code
0960-894X(1996)6:14<1715:GMA-SA>2.0.ZU;2-4
Abstract
Analogs of GPI membrane anchor precursors were prepared from chiral in ositol 1 and evaluated as substrates in rodent and trypanosomal cell-f ree incubates. Di-octanoyl GlcN alpha-PI 5b was an efficient mannose a cceptor whereas di-palmitoyl GlcN alpha-PI 5a was unexpectedly refract ory. Di-octanoyl beta-anomer 8 was mannosylated only under conditions that permitted acylation of the inositol residue. Copyright (C) 1996 E lsevier Science Ltd