Jp. Mulier et H. Vanaken, COMPARISON OF ELTANOLONE AND PROPOFOL ON A PRESSURE-VOLUME ANALYSIS OF THE HEART, Anesthesia and analgesia, 83(2), 1996, pp. 233-237
We designed a randomized study to compare the effect of eltanolone and
propofol on cardiac contractility. Patients were anesthetized, trache
ally intubated and ventilation controlled. Propofol, 1.25 or 2.5 mg/kg
, or eltanolone, 0.5 or 1 mg/kg, or a lipid emulsion only was administ
ered in an intravenous (IV) bolus dose. Pressure-volume analysis was u
sed based on radial artery pressure and transesophageal left ventricul
ar cross-sectional area. Both propofol and eltanolone have negative in
otropic properties in humans. We conclude that equianesthetic doses of
these drugs produce similar changes in myocardial contractility.