COMPARISON OF ELTANOLONE AND PROPOFOL ON A PRESSURE-VOLUME ANALYSIS OF THE HEART

We designed a randomized study to compare the effect of eltanolone and propofol on cardiac contractility. Patients were anesthetized, trache ally intubated and ventilation controlled. Propofol, 1.25 or 2.5 mg/kg , or eltanolone, 0.5 or 1 mg/kg, or a lipid emulsion only was administ ered in an intravenous (IV) bolus dose. Pressure-volume analysis was u sed based on radial artery pressure and transesophageal left ventricul ar cross-sectional area. Both propofol and eltanolone have negative in otropic properties in humans. We conclude that equianesthetic doses of these drugs produce similar changes in myocardial contractility.