CHARACTERIZATION OF THE 3'-UTR SEQUENCE ENCODED BY THE AQP-1 GENE IN HUMAN RETINAL-PIGMENT EPITHELIUM

Authors
RUIZ A BOK D
Citation
A. Ruiz et D. Bok, CHARACTERIZATION OF THE 3'-UTR SEQUENCE ENCODED BY THE AQP-1 GENE IN HUMAN RETINAL-PIGMENT EPITHELIUM, Biochimica et biophysica acta. Biomembranes, 1282(2), 1996, pp. 174-178
Citations number
21
Categorie Soggetti
Biology,Biophysics
Journal title
Biochimica et biophysica acta. Biomembranes → ACNP
ISSN journal
00052736
Volume
1282
Issue
2
Year of publication
1996
Pages
174 - 178
Database
ISI
SICI code
0005-2736(1996)1282:2<174:COT3SE>2.0.ZU;2-C
Abstract
The complete 3' UTR sequence encoded by the human aquaporin-1 gene is reported. The sequence encompassed by two cDNA clones showed, 33 nucle otides of 5' UTR sequence, a coding sequence of 807 nucleotides and 18 86 nucleotides corresponding to the complete 3' UTR sequence. High sim ilarity with 3' UTR sequences from rat and mouse counterparts was foun d. Northern blot analysis of several human tissues revealed a 2.8 kbp transcript. These data confirm the existence of water channels in the human retinal pigment epithelium.