CHILDHOOD ACUTE LYMPHOBLASTIC-LEUKEMIA RELAPSE IN THE UTERINE CERVIX

Purpose: Extramedullary relapse outside the testes and CNS is rare in children with acute lymphoblastic leukemia (ALL). We describe a case o f a recurrence of ALL in the uterine cervix during hematopoietic remis sion. Results: Primary recurrence in the uterine cervix was diagnosed by cytology with immunochemistry 43 months after initial diagnosis. Sh e was successfully treated with systemic chemotherapy, without hystere ctomy or irradiation. She remains in second complete remission 54 mont hs after relapse. Conclusions: Immunocytochemistry using monoclonal an tibodies against cell surface antigens made the cytologic diagnosis of leukemic relapse in the uterine cervix possible. Systemic chemotherap y is the first treatment of choice for ALL recurrence in the genital t ract in a patient without poor prognostic factors in order to spare go nadal function and reproductive potential.