BCR ABL AND LEUKEMIA

Authors
BUTTURINI A ARLINGHAUS RB GALE RP
Citation
A. Butturini et al., BCR ABL AND LEUKEMIA, Leukemia research, 20(6), 1996, pp. 523-529
Citations number
87
Categorie Soggetti
Oncology,Hematology
Journal title
Leukemia research → ACNP
ISSN journal
01452126
Volume
20
Issue
6
Year of publication
1996
Pages
523 - 529
Database
ISI
SICI code
0145-2126(1996)20:6<523:BAAL>2.0.ZU;2-E
Abstract
This review focuses on the role of the chimeric BCR/ABL gene in leukem ia development. First, we discuss and update knowledge regarding the m olecular biology of BCR/ABL. We then review data regarding transformin g activity of BCR/ABL. Third, we discuss the complex interactions betw een BCR/ABL and leukemia phenotype. We conclude with a brief discussio n of possible therapeutic implications of these data. Copyright (C) 19 96 Elsevier Science Ltd.