2 ANTITUMOR RUTHENIUM(III) COMPLEXES SHOWING SELECTIVITY IN THEIR BINDING TOWARDS POLY(DG)CENTER-DOT-POLY(DC) AND POLY(DA)CENTER-DOT-POLY(DT)

Authors
HARTMANN M EINHAUSER TJ KEPPLER BK
Citation
M. Hartmann et al., 2 ANTITUMOR RUTHENIUM(III) COMPLEXES SHOWING SELECTIVITY IN THEIR BINDING TOWARDS POLY(DG)CENTER-DOT-POLY(DC) AND POLY(DA)CENTER-DOT-POLY(DT), Chemical communications, (15), 1996, pp. 1741-1742
Citations number
17
Categorie Soggetti
Chemistry
Journal title
Chemical communications → ACNP
ISSN journal
13597345
Issue
15
Year of publication
1996
Pages
1741 - 1742
Database
ISI
SICI code
1359-7345(1996):15<1741:2ARCSS>2.0.ZU;2-C
Abstract
The antitumour-active complexes trans-Him[(RuCl4)-Cl-III(im)(2)] (Him = imidazole) and trans-Hind[RumCl(4)(ind)(2)] (Hind = indazole) bind a t a higher binding rate to poly(dG). poly(dC), compared to poly(dA). p oly(dT); the covalent binding to the nucleobases requires a preceding aquation of the compounds, similar to cisplatin.