COMPARISON OF TC-99M MIBI AND TL-201 TC-99M PERTECHNETATE FOR DIAGNOSIS OF PRIMARY HYPERPARATHYROIDISM/

The purpose of this study was to directly compare the efficacy of Tc-9 9m MIBI with Tl-201/Tc-99m pertechnetate scintigraphy for localizing p arathyroid adenomas in patients with primary hyperparathyroidism. Of 2 1 patients suspected of having primary hyperparathyroidism who had und ergone both studies, 14 had subsequent surgery and pathologic correlat ion. Based on the surgical and pathologic results, Tc-99m MIBI yielded 13 true-positive and 1 false-negative result. Thallium-201/Tc-99m per technetate imaging yielded eight true-positive, four false-negative, a nd two nondiagnostic studies because of lack of Tc-99m pertechnetate u ptake from thyroid hormone suppression. In conclusion, Tc-99m MIBI sci ntigraphy is an accurate method for localizing parathyroid adenomas in patients with primary hyperparathyroidism and the results suggest tha t it is superior to using Tl-201/Tc-99m pertechnetate.