NEW ALPHA-SEMICARBAZONE, BETA-SEMICARBAZONE AND GAMMA-SEMICARBAZONE AND THIOSEMICARBAZONE 1,3-DITHIOLANES AS RADIOPROTECTORS - ANTICONVULSANT ACTIVITY

Ten semicarbazone and nine thiosemicarbazone 1,3-dithiolanes (alpha, b eta and gamma) were prepared and tested as radioprotector agents. Dith iolane is well known for its radioprotective properties; this compound protects 78% of mice if 500 mg/kg Is administered 15 min before a 850 cGy irradiation dose [1]. For the first time, the combination of a se micarbazone or thiosemicarbazone group with a dithiolane moiety has be en achieved within a single molecule. We also studied the potential an ticonvulsant activities of these compounds, since benzodiazepines have been observed to greatly decrease radioinduced convulsions. Among the tested compounds, the correlation between the anticonvulsant activity and the radioprotective effect was not systematic.