CENTRO-PELVIC FAST-GROWING CANCER OF THE UTERINE CERVIX - ANALYSIS OFA SERIE OF 20 CASES

Twenty cases of fast growing cancer of the uterine cervix (14 IB, thre e IIA, three IIB FIGO), the definition of which is specified have been reviewed and compared to a cohort of 160 cases not having this featur e, to assess their outcomes. rn regard to fast growing carcinomas, the median age was 41 (25-50) years and the median follow-up 22 months (8 -213) as compared to 54 years (27-79) and 80 months (5-199) for the re ference cohort. The comparison of the two cohorts shows only a differe nce of breakdown which concerns the pelvic lymph nodes status (P < 0.0 5, chi(2)) Thirteen deaths are reported in the fast growing series ins tead of 54 in the other series. The 5-year overall survival is respect ively 34% (13-55) versus 74% (68-82), the loco-regional free survival 58% (33-84) versus 85% (79-81) (P < 0.001), the 5-year metastasis free survival 61% (38-84) versus 84% (78-90) (P = 0.004). This particular form needs a multidisciplinary approach and the local regional treatme nt has to be intensified.