INTERACTION OF BLEOMYCIN AND THEIR OLIGON UCLEOTIDE DERIVATIVES WITH NUCLEIC-ACIDS

Interaction of antitumor glycopeptide antibiotic bleomycin with nuclei c acids are examined. Equilibrium binding constant data obtained vario us physico-chemical methods are collected and compared. Contributions of N- and C-terminal domains of glycopeptide molecule to binding with DNA and sequence-specificity of DNA cleavage are discussed. The data o f the recently created compounds bleomycin-oligonucleotide conjugates are given. This conjugates possess simultaniously DNA-cleaving activit y of antibiotic (in catalytic manner also) and high selectivity to cho sen nucleotide sequence.