THE REACTION OF HUMAN GASTRIC-CANCER TRAN SPLANTANTS TO CYTOSTATICS DURING THEIR GROWTH UNDER THE RENAL CAPSULE OF MICE

By means of subrenal capsule assay (SCA) the reaction to cytostatics o f 52 gastric cancer specimens (33 - adenocarcinomas, 10 - ring-shaped cells cancer, 9 - mixed form of cancer) were investigated. The carcino mas of stomach grow comparatively slow under the renal capsule of the immunodepressed mice. This is an obstacle for the investigation of dru g sensitivity for at least 40% of them. The average effect of cytostat ics was about 80.0- 90.0% of inhibition of the tumor growth. Only the effect of 5-fluorouracil was 2.0-2.7% of regression of transplants. Th e received data agree with the clinical observations and show the expe diency of using of SCA at least for the identification of cases of ind ividual drug resistance of human gastric carcinomas.