ACUTE ARTERIAL THROMBOSIS DUE TO PLATELET-AGGREGATION IN A PATIENT RECEIVING GRANULOCYTE-COLONY-STIMULATING FACTOR

We describe a 44-year-old man with non-Hodgkin's lymphoma receiving gr anulocyte colony-stimulating factor (G-CSF) who developed an acute art erial thrombosis. The removed thrombus contained large amounts of plat elet aggregation. A rapid increase of platelets and increased adenosin e diphosphate (ADP)- and collagen-induced platelet aggregation were ob served at the time of the thrombotic event. A challenge test of G-CSF showed an increase in the platelet count and an augmentation of ADP- a nd collagen-induced platelet aggregation. In the use of G-CSF, patient s who produce a rapid increase in platelet levels could be at greater risk for thrombotic events and need to be followed-up carefully.