MYOSIN AND KINESIN - MOTHER AND CHILD REUNITED

The recent solution of the crystal structure of the kinesin motor doma in reveals striking similarities to the core region of the myosin moto r domain, implying a strong evolutionary relationship between these tw o motors. However, a complete understanding of the way that motility i s generated will require additional structural information, which may explain how the two motors have adapted to their fundamentally differe nt linear substrates, F-actin and microtubules.