PHENYL)-1-(3-METHYL-2-PYRIDYL)PYRROLIDIN-2,5-DIONE

The title compound, C16H13BrN2O2, is one of the 27 phenylsuccinimides for which the correlation between structure and anticonvulsant activit y was examined in an earlier study. All of the possible minimum-energy conformations for all of the compounds were found using molecular mod elling, For eight of the 27 derivatives the X-ray structures were dete rmined and these were used as a guide to find the correct conformation s among the minimum-energy conformations derived from calculations. Th e results of the present study show that the title compound also has a conformation similar to that calculated previously which confirms tha t the correct conformation was selected to calculate the structure-act ivity correlations.