INTERACTION BETWEEN CELL-SURFACE-EXPRESSED 70-KILODALTON HEAT-SHOCK PROTEIN-LIKE ANTIGEN AND CD3(-)8(-) KILLER T-CELLS()4()

Authors
TAKASHIMA S SATO N KISHI A TAMURA Y SAGAE S KUDO R TORIGOE T YAGIHASHI A KIKUCHI K
Citation
S. Takashima et al., INTERACTION BETWEEN CELL-SURFACE-EXPRESSED 70-KILODALTON HEAT-SHOCK PROTEIN-LIKE ANTIGEN AND CD3(-)8(-) KILLER T-CELLS()4(), Artificial organs, 20(8), 1996, pp. 857-861
Citations number
21
Categorie Soggetti
Engineering, Biomedical
Journal title
Artificial organs → ACNP
ISSN journal
0160564X
Volume
20
Issue
8
Year of publication
1996
Pages
857 - 861
Database
ISI
SICI code
0160-564X(1996)20:8<857:IBC7HP>2.0.ZU;2-B
Abstract
The 70-kilodalton heat shock proteins may be expressed on the cell sur face by an unknown mechanism and may interact with CD3(+)4(-)8(-) T ce ll receptor-alpha beta(-) killer (DNT) cells. In this interaction, cer tain cellular nascent or mutant peptides may be important (the complex es of 70-kilodalton heat shock protein and cellular peptides directly interact with DNT cells). The results imply that the interaction betwe en 70 kilodalton heat shock proteins and DNT cells may also work in gr aft rejection. By using antibodies that react with the cell surface-ex pressed 70-kilodalton heat shock proteins, one may overcome graft reje ction.