ON THE SYNTHESIS OF PLATELET-ACTIVATING-FACTOR VIA ACETYLATION OF 1-ALKYL-SN-GLYCERO-3-PHOSPHOCHOLINE - FORMATION OF STRUCTURAL ISOMER OF PAF IN THE PRESENCE OF BASES
Vv. Chupin et al., ON THE SYNTHESIS OF PLATELET-ACTIVATING-FACTOR VIA ACETYLATION OF 1-ALKYL-SN-GLYCERO-3-PHOSPHOCHOLINE - FORMATION OF STRUCTURAL ISOMER OF PAF IN THE PRESENCE OF BASES, Chemistry and physics of lipids, 81(1), 1996, pp. 35-43
It has been shown that platelet-activating factor (PAF) specimens prep
ared via acetylation of 1-alkyl-sn-glycero-3-phosphocholine (lyso-PAF)
with acetic anhydride are heterogeneous. The contaminated compound wa
s isolated and identified to be the structural isomer of PAF, 1-alkyl-
3-acetyl-sn-glycero-2-phosphocholine (iso-PAF). It appeared, that iso-
PAF is formed when performing the reaction in the presence of organic
bases, but not under acid catalysis. The mechanism of iso-PAF formatio
n is discussed.