ON THE SYNTHESIS OF PLATELET-ACTIVATING-FACTOR VIA ACETYLATION OF 1-ALKYL-SN-GLYCERO-3-PHOSPHOCHOLINE - FORMATION OF STRUCTURAL ISOMER OF PAF IN THE PRESENCE OF BASES

Authors
CHUPIN VV OSTAPENKO OV KLYKOV VN ANIKIN MV SEREBRENNIKOVA GA
Citation
Vv. Chupin et al., ON THE SYNTHESIS OF PLATELET-ACTIVATING-FACTOR VIA ACETYLATION OF 1-ALKYL-SN-GLYCERO-3-PHOSPHOCHOLINE - FORMATION OF STRUCTURAL ISOMER OF PAF IN THE PRESENCE OF BASES, Chemistry and physics of lipids, 81(1), 1996, pp. 35-43
Citations number
30
Categorie Soggetti
Biology
Journal title
Chemistry and physics of lipids → ACNP
ISSN journal
00093084
Volume
81
Issue
1
Year of publication
1996
Pages
35 - 43
Database
ISI
SICI code
0009-3084(1996)81:1<35:OTSOPV>2.0.ZU;2-#
Abstract
It has been shown that platelet-activating factor (PAF) specimens prep ared via acetylation of 1-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) with acetic anhydride are heterogeneous. The contaminated compound wa s isolated and identified to be the structural isomer of PAF, 1-alkyl- 3-acetyl-sn-glycero-2-phosphocholine (iso-PAF). It appeared, that iso- PAF is formed when performing the reaction in the presence of organic bases, but not under acid catalysis. The mechanism of iso-PAF formatio n is discussed.