Sm. Dursun et Ma. Reveley, THE EFFICACY OF A DOSE-ESCALATED APPLICATION OF TRANSDERMAL NICOTINE PLUS SULPIRIDE IN TOURETTES-SYNDROME, European psychiatry, 11(4), 1996, pp. 204-206
The addition of a dose-escalated regimen of transdermal nicotine patch
es (TNP) improved ties of a non-smoker patient with Tourette's syndrom
e, whose ties did not respond to sulpiride. This improvement, as asses
sed by the Yale Global Tic Severity Scale, lasted for up to 8 weeks, b
ut not 16 weeks. An explanation for the efficacy of TNP is presented.