PROSPECTIVE ASSESSMENT OF MORTALITY AMONG A COHORT OF PREGNANT-WOMEN IN RURAL MALAWI

Maternal mortality has recently received attention as a neglected publ ic health problem in many developing countries where mortality rates a re estimated to be 8-200 times those in developed countries. Most mate rnal mortality estimates in sub-Saharan Africa have used retrospective methods because of the lack of large population-based studies. The Ma ngochi Malaria Research Project, a trial of antimalarial chemoprophyla xis in pregnant women, provided an opportunity to examine prospectivel y mortality among the study women. Among 4,053 monitored pregnant wome n, 27 women were known to have died during pregnancy, labor, delivery and the one-year follow-up period. Three women died during the antenat al period and 12 died within six weeks of delivery for an estimated ma ternal mortality rate of 370 per 100,000 pregnant women; this rate was consistent with rates reported from retrospective surveys in Malawi. Twelve women died between three and 10 months after delivery, and the mortality rate in this nonmaternal period was estimated to be 341 per 100,000. Mortality rates in the maternal and nonmaternal periods were surprisingly similar. Human immunodeficiency virus type-1 (HIV-1) infe ction and anemia were strongly associated with death in the nonmaterna l period. Mortality among infants of mothers who died was 3.7 times hi gher than the rate of death among infants born to mothers who survived . This study highlights that for rural Malawian women, pregnancy and d elivery are risky periods, that the death of the mother adversely affe cts the survival of her children, and that HIV and anemia are importan t contributors to nonmaternal mortality in reproductive-age women. Str ategies to reduce mortality among women of child-bearing age in sub-Sa haran Africa must focus on decreasing the complications of pregnancy a nd delivery, and address important preventable causes of death, such a s anemia and HIV infection.