The trigeminal nerve is described in terms of segmental anatomy and re
gional pathology. The common brain stem lesions are neoplasms, vascula
r disease, and demyelinating processes. Common lesions affecting the c
isternal segment and Meckel's cave are schwannoma, meningioma, epiderm
oid, vascular ectasia, and aneurysm. Common lesions affecting the cave
rnous segment include meningioma, trigeminal schwannoma, lymphoma, met
astasis, and vascular lesions. Skull base abnormalities include chordo
ma, chondrosarcoma, metastasis, bone dysplasias, and Paget's disease.
The peripheral divisions of the trigeminal nerve are commonly involved
by adjacent inflammatory disease in the sinuses, perineural spread of
malignancy, and schwannoma. Unfortunately, the anatomic site of a les
ion cannot be accurately predicted on the basis of clinical symptomato
logy. Successful imaging evaluation must include the entire course of
the trigeminal nerve from the brain stem and upper cervical cord throu
gh the peripheral branches.