SERTRALINE IN THE TREATMENT OF SEVERE AGGRESSIVENESS IN HUNTINGTONS-DISEASE

Sertraline, a selective serotonin reuptake inhibitor, was used to trea t two consecutive cases of genetically confirmed Huntington's disease in which severe irritability and aggressiveness required inpatient adm ission. The complete cessation of aggressive behavior ill both cases h as been maintained on follow-up. This report adds to the literature im plicating serotonergic mechanisms in irritability and aggressiveness i n both neuropsychiatric and idiopathic psychiatric disorders.