NEUROPSYCHIATRIC SIDE-EFFECTS RELATED TO TREATMENT WITH FELBAMATE

Authors
MCCONNELL H SNYDER PJ DUFFY JD WEILBURG J VALERIANO J BRILLMAN J CRESS K CAVALIER J
Citation
H. Mcconnell et al., NEUROPSYCHIATRIC SIDE-EFFECTS RELATED TO TREATMENT WITH FELBAMATE, The Journal of neuropsychiatry and clinical neurosciences, 8(3), 1996, pp. 341-346
Citations number
17
Categorie Soggetti
Neurosciences,"Clinical Neurology",Psychiatry
Journal title
The Journal of neuropsychiatry and clinical neurosciences → ACNP
ISSN journal
08950172
Volume
8
Issue
3
Year of publication
1996
Pages
341 - 346
Database
ISI
SICI code
0895-0172(1996)8:3<341:NSRTTW>2.0.ZU;2-0
Abstract
Seven patients with refractory seizure disorders and neuropsychiatric symptoms believed secondary to felbamate are presented. Five were on c oncomitant valproic acid (rind other agents). Anergia, apathy, bradyph renia, and increased irritability were prominent. One patient on felba mate monotherapy had a new-onset psychosis. Felbamate's NMDA receptor antagonism and GABA potentiation (perhaps enhanced by valproic acid us e) are discussed as possible mechanisms of these side effects.