EVALUATION OF PHTHALMUSTINE, A NEW ANTICANCER COMPOUND .2. TUMOR INHIBITORY EFFECT IN MURINE EHRLICH ASCITES-CARCINOMA AND SARCOMA-180

Authors
BHATTACHARYA S GHOSH M SADHU U DUTTA S SANYAL U
Citation
S. Bhattacharya et al., EVALUATION OF PHTHALMUSTINE, A NEW ANTICANCER COMPOUND .2. TUMOR INHIBITORY EFFECT IN MURINE EHRLICH ASCITES-CARCINOMA AND SARCOMA-180, Neoplasma, 43(3), 1996, pp. 209-213
Citations number
11
Categorie Soggetti
Oncology
Journal title
Neoplasma → ACNP
ISSN journal
00282685
Volume
43
Issue
3
Year of publication
1996
Pages
209 - 213
Database
ISI
SICI code
0028-2685(1996)43:3<209:EOPANA>2.0.ZU;2-G
Abstract
The antitumor activity of phthalmustine (Neoplasma, 41, 1994, 35) has been evaluated in murine Ehrlich ascites carcinoma (EAC) and sarcoma-1 80 (S-180). The hematological changes associated with the application of phthalmustine were also evaluated in tumor bearing as well as in no rmal male Swiss mice. The results indicate that phthalmustine induces marked inhibition of tumor growth and substantially prolongs host surv ival having curative effect while it does not adversely affect hematop oiesis at the optimum dose tested No toxic symptoms were noted with re spect to external appearance, body weight changes and behavioral patte rn.