Rats were trained to discriminate an aqueous compound of an odor and t
aste (amyl acetate and NaCl) from the components of the compound befor
e removal of one olfactory bulb and the contralateral ventrolateral fr
ontal cortex. In postoperative tests, experimental rats performed much
more poorly than nonlesioned controls or controls which had all lesio
ns made in the same hemisphere. However, there were no significant dif
ferences among groups on tests for detection of amyl acetate and NaCl.
These results provide evidence that integration of taste and smell in
the production of flavor occurs in the ventrolateral frontal cortex.