DEGRADATION OF HYALURONIC-ACID KINETIC-STUDY AND THERMODYNAMICS

Authors
TOKITA Y OKAMOTO A
Citation
Y. Tokita et A. Okamoto, DEGRADATION OF HYALURONIC-ACID KINETIC-STUDY AND THERMODYNAMICS, European Polymer Journal, 32(8), 1996, pp. 1011-1014
Citations number
10
Categorie Soggetti
Polymer Sciences
Journal title
European Polymer Journal → ACNP
ISSN journal
00143057
Volume
32
Issue
8
Year of publication
1996
Pages
1011 - 1014
Database
ISI
SICI code
0014-3057(1996)32:8<1011:DOHKAT>2.0.ZU;2-G
Abstract
The hydrolytic degradation of hyaluronic acid (HA) was investigated by kinetic measurements. The first-order rate constants of the hydrolyti c degradation of HA at different pH and temperature were obtained on t he basis of the decrease in the molecular weight of HA. In addition, f rom the rate constant, we obtained the activation entropy (Delta S) a nd enthalpy (Delta H), and under all conditions studied the experimen tal data gave linear plots according to an isokinetic relationship. Co pyright (C) 1996 Elsevier Science Ltd.