INHIBITION OF FERROUS-INDUCED LIPID-PEROXIDATION BY DIPYRIDAMOLE, RA-642 AND MOPIDAMOL IN HUMAN LUNG-TISSUE

Authors
DELACRUZ JP OLVEIRA C GONZALEZCORREA JA BENITEZ A DELACUESTA FS
Citation
Jp. Delacruz et al., INHIBITION OF FERROUS-INDUCED LIPID-PEROXIDATION BY DIPYRIDAMOLE, RA-642 AND MOPIDAMOL IN HUMAN LUNG-TISSUE, General pharmacology, 27(5), 1996, pp. 855-859
Citations number
30
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
General pharmacology → ACNP
ISSN journal
03063623
Volume
27
Issue
5
Year of publication
1996
Pages
855 - 859
Database
ISI
SICI code
0306-3623(1996)27:5<855:IOFLBD>2.0.ZU;2-S
Abstract
1. The in vitro production of ferrous induced lipid peroxidation was 5 .71 times higher in rat lung tissue than in human lung membranes. 2. T he pyrimido-pyrimidine derivative RA-642 shows a more potent inhibitio n of ferrous-induced lipid peroxidation than dipyridamole; mopidamol h ad no effect. All the compounds showed higher antiperoxidative effect in rat than in human lung tissue.