INFLUENCE OF TRIFLUOPERAZINE AND VERAPAMIL ON THE ISOLATED-PERFUSED RAT-KIDNEY

1. Isolated rat filtering kidneys were perfused with Ringer bicarbonat e solutions containing either trifluoperazine (TFP, 50 mu M) or verapa mil (VER, 100 mu-M) to prevent tissue dysfunctions observed during per fusion. 2. Water, sodium and chloride kidney contents diminished under both treatments as compared with control preparations, and potassium content increased. 3. When albumin concentration was increased (10 g % ) in the perfusion medium (nonfiltering kidney preparation) these effe cts of TFP or VER were not observed. 4. Lipid peroxidation and LDH rel ease diminished significantly under 50 mu M TFP but only slightly unde r 100 mu M VER.