SOMATIC HYPERMUTATION OCCURS IN B-CELLS OF TERMINAL DEOXYNUCLEOTIDYL TRANSFERASE-DEFICIENT, CD23-DEFICIENT, INTERLEUKIN-4-DEFICIENT, IGD-DEFICIENT AND CD30-DEFICIENT MOUSE MUTANTS

Authors
TEXIDO G JACOBS H MEIERING M KUHN R ROES J MULLER W GILFILLAN S FUJIWARA H KIKUTANI H YOSHIDA N AMAKAWA R BENOIST C MATHIS D KISHIMOTO T MAK TW RAJEWSKY K
Citation
G. Texido et al., SOMATIC HYPERMUTATION OCCURS IN B-CELLS OF TERMINAL DEOXYNUCLEOTIDYL TRANSFERASE-DEFICIENT, CD23-DEFICIENT, INTERLEUKIN-4-DEFICIENT, IGD-DEFICIENT AND CD30-DEFICIENT MOUSE MUTANTS, European Journal of Immunology, 26(8), 1996, pp. 1966-1969
Citations number
33
Categorie Soggetti
Immunology
Journal title
European Journal of Immunology → ACNP
ISSN journal
00142980
Volume
26
Issue
8
Year of publication
1996
Pages
1966 - 1969
Database
ISI
SICI code
0014-2980(1996)26:8<1966:SHOIBO>2.0.ZU;2-O
Abstract
We show through sequence analysis of rearranged immunoglobulin variabl e (Ig-V) region genes from memory B cells of mouse mutants generated b y gene targeting that terminal deoxynucleotidyl transferase, CD23, int erleukin-4, IgD and CD30 are dispensable for somatic hypermutation.